Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Abstract

A fundamental view of neuroscience is that, in addition to neuronal activity, the structure of the brain constrains and explains brain function. An alluring formalism in computational neuroscience has been the generation of structural eigenmodes of neural activity from a matrix representing the anatomy of the brain. Traditionally, brain connectomics has been the gold standard for the coupling between structure and function. However, it has recently been suggested that simpler brain geometry can provide more explanatory power in fMRI. An adjacent modality is the source localization problem of EEG, which aims to identify the underlying generators of EEG recordings. The underdetermined nature o..